Ghrelin thesis

J Res Med Sci. This article has been cited by other articles in PMC.

Ghrelin thesis

J Res Med Sci. This article has been cited by other articles in PMC. Acylated ghrelin, biologically active form of ghrelin, activates growth hormone GH secretagogue receptor 1a and play a role in regulating of energy balance. The purpose of this study was to survey relationships between acylated ghrelin with GH, insulin resistance, lipid profile, and cardio respiratory function in lean and obese men.

Nineteen obese men body mass index After 12 hour fasting, Ghrelin thesis samples were collected and blood parameters as well as maximal oxygen uptake as indicator of cardiorespiratory function was assessed. Obese and lean inactive young men had different levels of acylated ghrelin, GH, insulin, insulin resistance index, cardiorespiratory function and body fat percent.

Body fat percent, insulin, and GH levels appear to be best determinant factors of acylated ghrelin levels. Also, in both obese and lean young men, higher levels of cardiovascular function were associated with higher levels of acylated ghrelin.

Adipose, Obesity, Insulin Resistance Index, VO2max, Gherlin Ghrelin is a gastric peptide stimulating pituitary growth hormone GH secretion and regulating feeding behavior and adiposity. Recognition of these relationships and other homeostatic factors that likely determine plasma acylated ghrelin levels can play a key role in understanding of acylated ghrelin interactions.

Ghrelin thesis

Likewise, the underlying mechanisms that mediate changes of systemic acylated ghrelin secretion are not well known. In addition, it is not clear whether endocrine or paracrine effects of acylated ghrelin are more physiologically relevant in the regulation of insulin secretion.

We expect that study of plasma acylated ghrelin relations to GH, insulin, glucose, insulin resistance index, and lipid profiles, and comparing these relations between lean and obese subjects can partially contribute in manifesting of above topics.

Moreover, respecting the confirmed effects of regular physical activities on plasma ghrelin levels, plasma acylated ghrelin relations to maximal oxygen uptake VO2max were studied in obese and lean men.

Considering insufficient available data, especially in Iranian population, the aim of this study was to investigate relationships between acylated ghrelin with GH, insulin resistance, lipid profile, and cardiorespiratory function in lean and obese men.

General characteristics of subjects are given in table 1. All subjects were inactive not exercising regularly in six months before initiation of the study. After signing a written informed consent, all subjects were medically examined by a physician before they entered the study and completed a questionnaire to ensure that they were not taking any medication, were not smokers, free of cardiac, respiratory, renal or metabolic diseases, were not under any diets and were not using steroids.

Table 1 Open in a separate window Study Design and protocol All assessments carried out during seven successive days and at On the 1st day, via an explanation session, aims, design, methodology, laboratory assessments e.

During the 2nd-4th days, the subjects had to rest and no exercise other than activities of daily living was permitted.

Height, weight, body mass index BMIbody fat percent and rest heart beat were measured on the 5th day. Subjects were weighed on a digital balance accurate to 0. Height was obtained to the nearest 0. Subcutaneous fat was measured to the nearest 1 mm using a caliper Harpenden, UK.

Then, body density was calculated via Jackson and Pollock formula.

An Investigation into the pharmacology of the ghrelin receptor - Enlighten: Theses

On the 6th day, after 12 hour overnight fasting, blood samples were obtained 5 ml EDTA-blood and 5 ml serum from the forearm vein of the subjects. Serum blood was centrifuged after 1h at room temperature.

On the last day, maximal oxygen uptake VO2max values of subjects were estimated using Astrand-Rhyming submaximal cycle ergometer test Robimax, Taiwan. Independent Student's t-tests were used to compare characteristics between lean and obese groups. Relationships between acylated ghrelin and other parameters were calculated by Pearson's correlation analysis.

Ghrelin thesis

Before statistical analyses were performed, Kolmogorov-Smirnov test was used to test normal distribution of data.

P value of less than 0. Statistical analyses were performed using SPSS software version Results There were no significant differences in age and height between obese and lean groups Table 2. Table 2 Open in a separate window BMI was significantly higher up to Body fat percent was significantly No significant differences were seen between the systolic or diastolic blood pressure of two groups.

Plasma acylated ghrelin levels were significantly Serum insulin concentrations were 3.Ghrelin in the blood is associated with obesity and obesity is associated with insulin resistance. Food intake regulation is a redundant system affected by tenth of factors of which ghrelin is.

Structure and Physiological Actions of Ghrelin

An Investigation into the pharmacology of the ghrelin receptor Bennett, Kirstie Ann () An Investigation into the pharmacology of the ghrelin receptor. PhD thesis, University of Glasgow. University of South Carolina Scholar Commons Theses and Dissertations The Role of Exercise Dose on Ghrelin Concentration in Postmenopausal Women.

Hormones of Energy Metabolism in Critically Ill Foals: Insulin, Glucagon, Leptin, Adiponectin, Ghrelin and Growth Hormone THESIS Presented in Partial Fulfillment of the Requirements for the Degree Master of Science in.

Bennett, Kirstie Ann () An Investigation into the pharmacology of the ghrelin receptor. PhD thesis, University of Glasgow. Full text available as. Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin O-acyl transferase.

Ghrelin is mainly produced by a subset of stomach cells and also by the hypothalamus, the pituitary, and other tissues. Scientifica is a peer-reviewed, Open Access journal that publishes.

Structure and Physiological Actions of Ghrelin